ZIF-8 with cationic defects toward efficient 125I2 uptake for in vitro radiotherapy of colon cancer
Xin-Xin Tian‡a, Yi-Tong Liu‡b, Yan Li a, Xin-Yu Qiu b, Wen-Hua Zhang, *a（张文华）David J. Young c and Qiu Chen*a（陈秋）
a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
b State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection (SRMP) of Soochow University, Suzhou 215123, China
c College of Engineering, Information Technology & Environment, Charles Darwin University, Darwin, Northern Territory 0909, Australia
‡ These authors contribute equally to this work.
Chem. Commun., 2022, 58, 6942--6945
Introducing 2,3-dimethyl-1H-imidazol-3-iumiodide (Dmim) as amonodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic ‘missing linker’ defects. ZIF-8 + (38) adsorbs 125I2 and the resulting radioactive host–guest complex exhibits in vitro cytotoxicity comparable to that of Na125I against colon cancer cell line CT26.
链接：//pubs.rsc.org/en/content/articlelanding/2022/cc/d1cc07304d
