Ruthenium(II)-Catalyzed Chelation-Assisted Desulfitative Arylation of Benzo[h]quinolines with Arylsulfonyl Chlorides
Yi-Xin Xu a, Yu-Qing Liang a, Zhong-Jian Cai* a（蔡忠建）,and Shun-Jun Ji * a b（纪顺俊）
a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China
b Suzhou Baolidi Functional Materials Research Institute, Suzhou 215144, China
Org. Lett. 2022, 24, 2601--2606
Herein, a novel chelation-assisted C−H arylation reaction of benzo[h]quinoline is described. This transformation, using [RuCl2(p-cymene)]2 as the catalyst and cheap and easily accessible arylsulfonyl chlorides as the arylation source, featured simple reaction conditions, a broad substrate scope, and functional group tolerance. The successful application of some bioactivemolecule- based sulfonyl chlorides further highlighted the potential utility and importance of this desulfitative C−H arylation protocol.
链接：//pubs.acs.org/doi/full/10.1021/acs.orglett.2c00542
