Ligand-Promoted Fluorinated Olefination of Isatins at the C5 Position via a Palladium Catalyst
Kehan Zhou1, Dongjie Wang1, Guodong Ju1, Zefeng Deng1, Pengcheng Huang1, Zhibin Huang1, Bao Li 2 ,*（李苞）,and Yingsheng Zhao1,2 ,*（赵应声）
1 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
2 School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, P. R. China
Org. Lett. 2022, 24, 5568--5572
A palladium-catalyzed nondirected fluorinated olefination was developed. The oxalyl amide ligand greatly improved the yield of the reaction. A wide variety of isatin derivatives were well tolerated and yielded the corresponding products in moderate to good yields. Various fluorinated olefins were also compatible. The application and synthesis of bioactive compounds such as a Metisazone derivative highlight the synthetic value of this approach.
链接：//pubs.acs.org/doi/10.1021/acs.orglett.2c02104
