Yingsheng Zhao*(赵应声)
Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University, Suzhou 215123, PR China
Org. Lett. 2015, 17, 1802–1805
A simple and practical exo-oxime ether auxilixary for ortho-C–H functionalization of aromatic alcohols has been developed. Selective olefination of aromatic alcohols were first achieved via a six- or seven-membered exo-acetone oxime ether palladacycle with broad substrate scope. In addition, the crystal of the exo-palladacycle intermediate was obtained for the first time, and the application of this method in total synthesis of 3-deoxyisoochracinic acid was accomplished via a novel retro-synthetic disconnection approach, thus demonstrating the utility of this transformation.
链接：
//pubs.acs.org/doi/abs/10.1021/acs.orglett.5b00594
