博彩平台

Highly efficient construction of a bridged pentacyclic skeleton via a six-component domino reaction under microwave irradiation

Lei Fu^a,   Xian Feng^a,   Juan-Juan Zhang^a,   Jun-Die Hu^a,   Zhan Xun^a,   Jian-Jun Wang^a,   Zhi-Bin Huang  and   Da-Qing Shi^*(史达清)  

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P.R. China

Green Chem. 2015, 17, 1535-1545

A novel bridged pentacyclic skeleton has been constructed via the six-component domino reaction of glutaraldehyde, malononitrile, cyclic 1,3-dicarbonyl compounds and amines under microwave irradiation. In this one-pot transformation, 11 new bonds and five new rings have been formed. The main advantages of this protocol are short reaction time (within 30 min), practical simplicity, high regioselectivity, benign solvents, atom-economy, and environmental friendliness.

链接：

//pubs.rsc.org/en/Content/ArticleLanding/2015/GC/c4gc01832j#!divAbstract