博彩平台

Combination of fluoroalkylation and Kornblum–DeLaMare reaction: a new strategy for the construction of (Z)-β-perfluoroalkyl enaminones

Chunmei Liu^a,   Erbo Shi^a,   Feng Xu^b,   Qiang Luo^a,   Hongxiang Wang^a,   Jijun Chen^a  and   Xiaobing Wan^*a(万小兵)

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China

Chem. Commun. 2015, 51, 1214-1217

A novel strategy has been developed for the highly chemo- and stereo-selective synthesis of (Z)-β-perfluoroalkyl enaminones from readily available starting materials via a multicomponent radical reaction involving sequential fluoroalkylation and Kornblum–DeLaMare reaction. Notably, this methodology involves the concurrent cleavage of at least three chemical bonds, including two C–F bonds and one C–X (X = Br or I) bond, as well as the formation of three new bonds, including one C[double bond, length as m-dash]O bond, one C[double bond, length as m-dash]C bond and one C–N bond, in one pot.

链接：

//pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C4CC07833K#!divAbstract