博彩平台

Highly selective synthesis of functionalized polyhydroisoquinoline derivatives via a three-component domino reaction

Xian Feng^a,   Jian-Jun Wang^a,   Zhan Xun^a,   Juan-Juan Zhang^a,   Zhi-Bin Huang^a  and   Da-Qing Shi^*a(史达清)

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China

Chem. Commun. 2015, 51, 1528-1531

Two series of novel functionalized polyhydroisoquinoline derivatives have been synthesized via the three-component domino reaction of glutaraldehyde and malononitrile with a series of β-ketoamides under microwave irradiation conditions in the presence of a catalytic amount of Et₃N (10 mol%). This reaction represents the first reported process for the facile conversion of a β-ketoamide to a hydroisoquinoline via a C–N bond cleavage reaction without the need for a multistep reaction process.

链接：

//pubs.rsc.org/en/content/articlelanding/2015/cc/c4cc08900f#