Shun-Jun Ji*(纪顺俊)
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China
Adv. Synth. Catal. 2015, 357, 823–828
A novel and efficient cobalt-catalyzed oxidative isocyanide insertion with amines via two C—N bond formation reactions under ultrasound irradiation conditions has been developed. This protocol provides a simple, clean and general way to synthesize guanidines or their corresponding hydrochlorides from simple starting materials under ultrasonic conditions. This chemistry could also be applied to an efficient synthesis of optically active guanidines without loss of enantioselectivity.
链接：
//onlinelibrary.wiley.com/doi/10.1002/adsc.201400911/abstract
