Xiaobing Wan*,†(万小兵)
† Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
‡ Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou 213164, China
Org. Lett. 2014, 16, 6350−6353
A new radical-polar crossover reaction has been developed involving the combination of a tandem radical reaction and Kornblum−DeLaMare rearrangement in a one-pot process. This simple methodology allows for the construction of polyfunctionalized carbonyl compounds via the oxidative coupling of 1,3-dioxolanes with electron-deficient alkenes and vinylarenes in the presence of Co(salen) and TBHP under mild conditions. This reaction also exhibited high functional group tolerance, wide substrate scope, and operational simplicity.
链接：
//pubs.acs.org/doi/pdf/10.1021/ol503128j
