博彩平台

Highly site-selective sequential alkenylation of oxalyl amide protected phenylpropylamine derivatives via a seven-membered palladacycle

Qian Wang^a,   Jian Han^a,   Chao Wang^a,   Jingyu Zhang^a,   Zhibin Huang^a,   Daqing Shi^*a (史达清)  and   Yingsheng Zhao^*a (赵应声)

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China

Chem. Sci. 2014, 5, 4962-4967

A protocol for palladium-catalyzed ortho C(sp2)–H alkenylation via a rarely reported seven-membered palladacycle with oxalyl amide as a directing group was reported. The range of olefins was the broadest yet reported for this kind of C–H alkenylation reaction. For example, allyl acetate, allyl alcohol derivatives, acraldehyde, acrylate and acrylonitrile were all tolerated in this C–H transformation. Sequential alkenylation reactions were also achieved to construct the complex olefinated arenes in good yields in one pot.

链接：

//pubs.rsc.org/en/Content/ArticleLanding/2014/SC/c4sc02172j