博彩平台

Easily Accessible Auxiliary for Palladium-Catalyzed Intramolecular Amination of C(sp2)—H and C(sp3)—H Bonds at δ- and ε-Positions^†

Chao Wang,   Changpeng Chen,   Jingyu Zhang,   Jian Han,   Qian Wang,   Kun Guo,   Pei Liu,   Mingyu Guan,   Dr. Yingming Yao*  (姚英明)  and   Prof. Dr. Yingsheng Zhao*  (赵应声)

^* Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University, Suzhou 215123 (P.R. China)

^† We are grateful to Dr. Aiwen Lei (Wuhan University) for helpful suggestions and comments on this manuscript. We gratefully acknowledge financial support from the Natural Science Foundation of Jiangsu Province of China (L210903913), and a start-up fund (Q410901212) from Soochow University for support of this work. The PAPD and Qing Lan Project are also gratefully acknowledged.

Angew. Chem. Int. Ed. 2014, 53, 9884-9888

An easily synthesized and accessible N,O-bidentate auxiliary has been developed for selective C—H activation under palladium catalysis. The novel auxiliary showed its first powerful application in C—H functionalization of remote positions. Both C(sp2)—H and C(sp3)—H bonds at δ- and ε-positions were effectively activated, thus giving tetrahydroquinolines, benzomorpholines, pyrrolidines, and indolines in moderate to excellent yields by palladium-catalyzed intramolecular C—H amination.

链接：

//onlinelibrary.wiley.com/doi/10.1002/anie.201404854/abstract