Shun-Jun Ji* (纪顺俊)
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, People's Republic of China
Chem. Commun. 2014, 50, 9718-9721
A metal-free method for direct C(sp3)–H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.
链接：
//pubs.rsc.org/en/content/articlehtml/2014/cc/c4cc04282d
