Xiaojing Wang, Huan Liu, Jingwen Li, Kaiguo Ding, Zhonglin Lv, Prof. Yonggang Yang, Prof. Hong Chen* (陈红) and Prof. Xinming Li*（李新明）
*College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (China)
Chem. Asian J. 2014, 9, 784–789.
Herein, we report a novel fluorescent “light-up” probe useful for carboxylesterase assay that is based on a tetraphenylethylene derivative containing carboxylic ester groups. The specific cleavage of the carboxylic ester bonds by carboxylesterase results in the generation of a relatively hydrophobic moiety that self-assembles into supramolecular microfibers, thus giving rise to “turn-on” fluorescent signals. A high sensitivity towards carboxylesterase was achieved with a detection limit as low as 29 pM, which is much lower than the corresponding assays based on other fluorescent approaches.
链接：
//onlinelibrary.wiley.com/doi/10.1002/asia.201301326/abstract
