Wen-Juan Hao †, Jian-Qiang Wang ‡, Xiao-Ping Xu †, Shi-Lei Zhang ‡, Shun-Yi Wang *†, (汪顺义) and Shun-Jun Ji *† （纪顺俊）
†Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, ‡College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
J. Org. Chem. 2013, 78 , 12362–12373
I2-promoted domino reactions of isatins or 3-hydroxyindolin-2-one derivatives with enaminones under O2 conditions have been established. The reactions of isatins with enaminones afforded functionalized tetracyclic pyrrolo[2,3,4-kl]acridine derivatives in moderate to good yields through domino cyclization and C–H oxidation. The reactions of 3-hydroxyindolin-2-one derivatives with enaminones proceeded well to give functionalized pyrrolo[2,3,4-kl]acridine derivatives via tandem ring-opening/recyclization/methyl migration sequences with two C–C bonds cleaved.
链接： //pubs.acs.org/doi/abs/10.1021/jo401773j
