I2/TBHP-Catalyzed Chemoselective Amination of Indoles
Zhong-Jian Cai , Shun-Yi Wang *（汪顺义）, and Shun-Jun Ji * （纪顺俊）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
Org. Lett. 2013, 15, 5226–5229
A novel I2/TBHP-mediated direct oxidative diamination reaction of indoles with anilines was developed. The reaction proceeded smoothly under aqueous and open air reaction conditions. This protocol provides a practical synthetic method for the synthesis of Tryptanthrin and the construction of N–C3 linked pyrrolidinoindolines which is the core structure of Psychotrimine.
链接： //pubs.acs.org/doi/abs/10.1021/ol4023936
