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A cyanobenzo[a]phenoxazine-based near infrared lysosome-tracker for in cellulo imaging

Ru Sun,^a   Wu Liu,^a   Yu-Jie Xu,^b   Jian-Mei Lu,*^a (路建美)  Jian-Feng Ge*^a （葛健锋）and   Masataka Ihara^c  

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^a College of Chemistry, Chemical Engineering and Material Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, 199 Ren'Ai Road, Suzhou 215123, China
^b School of Radiation Medicine and Protection, Medicine College of Soochow University, Suzhou 215123, China

^c Drug Discovery Science Research Centre, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Chem. Commun. 2013, 49, 10709-10711

A cyanobenzo[a]phenoxazine-based pH probe with pK_a = 5.0 exhibits OFF–ON emission at 625–850 nm upon excitation at 600 nm in aqueous buffers. The in cellulo imaging experiments with HeLa cells indicate that the probe can serve as a lysosome-specific probe under red light excitation (633 nm) with near infrared emission (650–790 nm).

链接： //pubs.rsc.org/en/content/articlelanding/2013/cc/c3cc46696e#!divAbstract