Highly Efficient Chemoselective Synthesis of Polysubstituted Pyrroles via Isocyanide-Based Multicomponent Domino Reaction
Xiang Wang , Xiao-Ping Xu , Shun-Yi Wang *（汪顺义）, Weiqun Zhou , and Shun-Jun Ji * （纪顺俊）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
Org. Lett. 2013, 15，4246–4249
A multicomponent domino reaction for the chemoselective, catalyst-free synthesis of polysubstituted pyrroles from readily available isocyanides, primary or secondary amines, and gem-diactivated olefins has been developed. Structurally diverse pyrroles were obtained in moderate to good yields under mild conditions.
链接： //pubs.acs.org/doi/abs/10.1021/ol401976w
