Highly Efficient Synthesis of Polysubstituted Pyrroles via Four-Component Domino Reaction
Xian Feng(冯贤), Qian Wang(王黔), Wei Lin(林伟), Guo-Lan Dou(窦国兰), Zhi-Bin Huang (黄志斌)*, Da-Qing Shi (史达清)*
Org. Lett. 2013, 15, 2542-2545.
A highly efficient, catalyst-free synthesis of polysubstituted pyrroles by means of a novel four-component domino reaction of an arylglyoxal monohydrate, an aniline, a dialkyl but-2-ynedioate, and malononitrile is reported. This transformation proceeded via a 6,6a-dihydrofuro[2,3-b]pyrrole as the key intermediate.
链接：//pubs.acs.org/doi/abs/10.1021/ol4010382 
