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Cobalt-catalyzed Oxidative Isocyanide Insertion to Amine Based Bisnucleophiles: Diverse Synthesis of Substituted 2-Aminobenzimidazoles, 2-Aminobenzothiazoles, and 2-Aminobenzoxazoles

Tong-Hao Zhu(朱同浩), Shun-Yi Wang(汪顺义),* Gao-Nan Wang(王高男) and Shun-Jun Ji (纪顺俊)*

Chem. Eur. J. 2013, 19,5850–5853

Cobalt catalysis: Synthesis of substituted 2-aminobenzimidazoles, 2-aminobenzothiazoles, and 2-aminobenzoxazoles was achieved by using cobalt(II) acetate catalyzed isocyanide insertion to o-diaminobenzene, 2-aminobenzenethiol, and 2-aminophenol derivatives in 1,4-dioxane (see scheme). It was found that the reaction proceeded efficiently to give the desired products in up to 95 % isolated yields by CN and CS (O, N) formation in a single step.

链接：//onlinelibrary.wiley.com/doi/10.1002/chem.201300239/abstract