Isocyanide-Based Multicomponent Reactions: Catalyst-Free Stereoselective Construction of Polycyclic Spiroindolines
Xiang Wang , Shun-Yi Wang *（汪顺义）, and Shun-Jun Ji * （纪顺俊）
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
Org. Lett. 2013, 15, 1954–1957.
A novel catalyst-free one-pot tandem reaction for the stereoselective construction of polycyclic spiroindolines was developed. This method offers a straightforward access to structurally diverse polycyclic spiroindoline derivatives in high yields (up to 90%) with excellent levels of diastereoselectivity.
链接： //pubs.acs.org/doi/abs/10.1021/ol400606c
