报告题目: Polymers for Molecular Delivery to Immune System
报告人: Prof. Chun WANG
Department of Biomedical Engineering
University of Minnesota
报告时间: 2013年12月12日（星期四）下午3:00-4:00
报告地点：独墅湖校区907号楼1445室
报告摘要: The human immune system plays critically important roles in all diseases. Therapeutics targeting the immune system usually include vaccines and immunomodulatory drugs. To be effective, immunotherapeutices must be delivered appropriately to the right cells and tissue locations in the body. Here I will discuss some of the unique opportunities and challenges in the development of polymeric drug delivery systems for immunotherapy. The first part of the talk deals with cationic polymer carriers for DNA vaccine delivery. Much effort is dedicated to understanding structure-function relationship of well-defined cationic polymers and nanoscale particles composed of polymer-condensed antigen-encoding DNA (called “polyplexes”) and how they interact with the most important type of antigen-presenting cells -- the dendritic cells. In the second part of the talk, I will introduce a new type of biodegradable semi-solid polymers with unique physicochemical properties and excellent biocompatibility, and demonstrate the potential use of such materials for delivering therapeutic vaccines and adjuvants against cancer.
报告人简介：Prof Chun Wang received his Ph.D. degree in Bioengineering with Jindrich Kopecek at the University of Utah in 2001. He was an NIH postdoctoral fellow with Robert Langer at Massachusetts Institute of Technology from 2001 to 2004. In 2004, he joined the faculty of the University of Minnesota, where he currently is an Associate Professor in Biomedical Engineering with courtesy appointments in Chemical Engineering and Material Science and Pharmaceutics. He serves on the editorial board of the Journal of Controlled Release (since 2005) and Advanced Drug Delivery Reviews (since 2010). He was the recipient of the National Science Foundation CAREER Award, Wallace H. Coulter Foundation Early Career Translational Research Award, and McKnight Land-Grant Professorship. He has published over 40 peer-reviewed research articles, 5 patents granted or pending, and given over 80 invited talks. His current research interest is polymer-based therapeutic biomaterials with applications in controlled drug delivery, immunotherapy, medical devices, and regenerative medicine.
