报告题目: Palladacycle Catalyzed Asymmetric P-H Addition Reactions
报告人: Professor Pak-Hing LEUNG (梁 百 興)
报告时间: 2013年11月20日（星期四）上午9：30
报告地点：独墅湖校区701号楼B501室
报告摘要: Chiral aza- and phospha-palladacycles are found to function as highly efficient catalysts for the asymmetric P-H addition reaction. The versatile protocol allows for the asymmetric hydrophosphination of olefenic C=C bonds thus yielding a family of tertiary C*-phosphines as well as C*P*-phosphines and diphosphines, depending on the nucleophile employed. The addition of two equivalents of HPPh2 to symmetrical bifunctionalized alkynes leading to generation of two new C* centers is also achievable. The air-sensitive nucleophiles and the unsaturated substrates containing unprotected functionalities such as aldeyhde, keto, ester, cyano and alcohol can be utilized directly under this mild and facile reaction conditions. The methodology is equally efficient when applied to the generation of P-N ligand systems via hydrophosphination of unsaturated pyridyl-based substrates as well as systems with C=N moieties. This synthetic strategy therefore offers to be a versatile approach for the generation of a wide range of chiral tertiary phosphine ligands with potential applications in further catalytic processes.
About the speaker:
Professor Pak-Hing LEUNG (梁 百 興) was born in Hong Kong (1956). Tertiary Education: Polytechnic of North London (BSc Hons 1982, FYP supervisor: Peter A Tasker), Australian National University (PhD 1986, supervisor: S. Bruce Wild), University of Toronto & University of Chicago (posdoc fellow, 1987-1989, supervisor: Brice Bosnich). He was Professor and Deputy Head of the Department of Chemistry at the National University of Singapore till 2005 after which he was invited to be the founding Head of the Chemistry Division of the new School of Physical and Mathematical Sciences (SPMS) at the Nanyang Technological University, Singapore. He has served as Vice-Dean at SPMS and Head of the Division of Chemistry and Biological Chemistry. So far, he has received a University Researcher Award (NUS, 1998), 14 Teaching Awards (since 1993, both from NUS and NTU). He has published more than 140 peer-reviewed articles in the area of asymmetric synthesis, stereochemistry of phosphorus and organometallic compounds.
