学术报告
报告题目：Dynamic host-guest interactions at the interface between supramolecular chemistry and materials science
报告人：Prof. Oren A. Scherman
Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, United Kingdom
报告时间：2013年11月1日（周五）下午2:00
报告地点：独墅湖校区907-1101
摘要：Our research interests include the development of controlled polymer architectures, hybrid nanoparticle assemblies, and the integration of dynamic supramolecular systems at interfaces. Using cucurbit[n]urils (CB[n]s) we adopt a simple bottom-up approach to achieve sophisticated designs, which are directed at the preparation of novel microcapsules, dynamic hydrogels, photonic devices and chemical and biological sensors.
Modification of solution viscosity using multivalent polymers has been accomplished through dynamic cross-linking in water using CB[8]. These hydrogels, with extremely high water content (up to 99.75% water by weight), have also been prepared by utilising renewable cellulose derivatives. Their rapid formation and shear-induced flow properties make these materials perfectly suited for use as injectable hydrogels for delivery of therapeutics. Indeed, model proteins can be easily encapsulated and their sustained release is observed over the course of 6 months. This far surpasses the current state-of-the-art for protein release from a hydrogel, highlighting these materials as important potential candidates for sustained therapeutic applications.
Furthermore, polymer-inorganic composite materials can be readily prepared based on the CB[8] coupling of multivalent gold nanoparticles (AuNPs) to functional copolymers. When these systems are attached onto gold surfaces intricate control is achieved over the site-selective immobilization of colloids and peptides. This has great scope for the development of optical materials, chemical sensors and biological separations. Additionally, we have developed an innovative new technique for manufacturing 'smart' microcapsules in large quantities using continuous flow in a single step from tiny droplets of water. The microdroplets are loaded with copolymers, AuNPs and CB[8]. The major advantage of this manufacturing platform over current methods is that a variety of cargos can be efficiently loaded during the microcapsule formation at room temperature, and the dynamic supramolecular interactions provide control over the porosity of the capsules and the timed release of their contents using stimuli. Our CB[n] based host-guest systems exhibit dynamic self assembly and are capable of responding to stimuli (photochemical, chemical, and thermal) allowing for external control and function to be built into the materials.
References
[1] aZhang, J.; Coulston, R.; Jones S.T.; Scherman, O.A.; Abell, C. Science, 2012, 335, 690-694. bRauwald, U.; Scherman, O. A. Angew. Chem. Int. Ed., 2008, 47, 3950-3953.
[2] aLee, T.C.; Scherman, O.A. Chem. Commun., 2010, 46, 2338-2440. bCoulston, R.; Jones, S.T.; Lee, T.C.; Appel, E.A.; Scherman, O.A. Chem. Commun., 2011, 47, 164-166.
[3] aTian, F.; Cheng, N.; Nouvel, N.; Geng, J.; Scherman, O.A. Langmuir, 2010, 26, 5323-5328. bTian, F.; Cziferszky, M; Jiao, D.; Wahlstr??m, K; Geng, J; Scherman, O.A. Langmuir, 2011, 27, 1387-1390.
[4] aAppel, E.A.; Rauwald, U.; Jones, S.; Zayed, J.M.; Scherman, O.A. J. Am. Chem. Soc., 2010, 132, 14251-14260. bAppel, E.A.; Loh, X.J.; Jones, S.T.; Dreiss, C.A.; Scherman, O.A. Biomaterials, 2012, 33, 4646-4652.
欢迎感兴趣的老师和同学参加！
Curriculum Vitae Oren A. Scherman
Education
PhD, Chemistry, California Institute of Technology February 2004
Thesis Title: Enhancing Materials through Controlled Architectures with Ring-Opening Metathesis Polymerization
BA, Chemistry, summa cum laude Cornell University May 1999
Honors Thesis: Controlling Polymer Architecture Through Functional Functionalized Initiators for Living Polymerization
Current Position
University of Cambridge, Cambridge, United Kingdom 2006~present
Director of the Melville Laboratory for Polymer Synthesis 2011~ Present University Reader in Supramolecular and Polymer Chemistry 2012~Present
Next Generation Fellow, Tsinghua University, Beijing, China October 2013~present
Tsinghua Xuetang Visiting Professor in Chemistry
Honors and Awards
RSC Hickenbottom Award 2013
SCI McBain Medal 2013
ERC Proof of Concept Grant 2011
RSC Macro Group UK Young Researchers Medal 2010
ERC Starting Investigator Grant 2009
RSC Harrison-Meldola Memorial Prize 2009
Walters-Kundert Next Generation Fellowship 2006~present
NSF MPS-DRF International Postdoctoral Fellowship 2004~2006
NSF Graduate Fellowship 1999{2002
Leo and Berdie Mandelkern Prize in Chemistry (Cornell University) 1999
National Science Scholar 1995
Phi Delta Kappa International Fellow 1995
Professional Memberships and Advisory Boards
Scienti_c Advisory Board SABIC IP
Scienti_c Advisory Board Aqdot
Advisory Board Chemical Communications 2012~present
Advisory Board International Conference on Cucurbituril Chemistry (ICCB) 2009~present
Royal Society of Chemistry (FRSC)
American Chemical Society (ACS)
Polymeric Materials: Science and Engineering Division (ACS)
Polymer Division (ACS)
