报告题目：Advancing Metallocene Polymers: from Controlled Polymerization to Macromolecular Templates and Medicinal Chemistry
报告人: Prof. Chuanbing Tang
Department of Chemistry and Biochemistry, University of South Carolina
报告时间: 2013年6月28日（周五）上午9:30-11:30
报告地点: 独墅湖校区907号楼1445室
Abstract
Metallopolymers combine synthetic efficiency and versatility of an organic polymer framework with unique properties of inorganic metals. Among a variety of metallopolymers, metallocene-containing polymers attract significant attention in materials science due to their high thermal stability, fully reversible redox chemistry and many other fascinating properties that arise from their sandwich-like structures. After nearly half-century development, the field of metallocene-containing polymers faces numerous challenges to re-invigorate new synthesis and applications. This presentation will highlight recent progress in synthesis and applications of side-chain metallocene-containing polymers with diverse architectures by controlled polymerization. Particularly, we will focus on a class of cationic 18-e cobaltocenium-containing polyelectrolytes prepared by reversible addition fragmentation transfer polymerization (RAFT) and ring-opening metathesis polymerization (ROMP). Both ion-exchange polyelectrolyte chemistry and robust template synthesis toward versatile advanced cobalt materials will be covered. Initial investigation on medicinal chemistry of these polyelectrolytes as anticancer drugs and antimicrobial agents will be discussed.
References:
1. Ren L.; Hardy C. G.; Tang C. Synthesis and Solution Self-assembly of Side-Chain Cobaltocenium-containing Block Copolymers, J. Am. Chem. Soc., 2010, 132, 8874-8875.
2. Ren L.; Zhang J.; Bai X.; Hardy C. G.; Shimizu K. D.; Tang C. Preparation of Cationic Cobaltocenium Polymers and Block Copolymers by “Living” Ring-Opening Metathesis Polymerization. Chem. Sci. 2012, 3, 580-583.
3. Zhang J.; Pellechia P. J.; Hayat J.; Tang C. Quantitative and Qualitative Counterion Exchange in Cationic Metallocene Polyelectrolytes. Macromolecules 2013, 46, 1618-1624.
