报告一：Development of advanced microstructures for tissue engineering
报告人: Prof. Dr. Dirk W. Grijpma
University of Twente,
Department of Biomaterials Science and Technology,
MIRA Institute for Biomedical Technology and Technical Medicine
报告地点: 独墅湖校区907号楼1445报告厅
报告时间: 2012年5月31日上午9:30-10:30
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报告摘要：
For tissue engineering of small-diameter blood vessels, biodegradable, flexible and elastic porous tubular structures are most suited. Poly(trimethylene carbonate) (PTMC) degrades in vivo by surface erosion. Elastic and flexible networks can be formed with high molecular weight PTMC by gamma irradiation. Crosslinked tubular porous PTMC structures were prepared, smooth muscle cells were seeded and cultured in a pulsatile flow system.
Stereolithography (SLA) is a rapid prototyping technique that allows the building of complex 3D structures. Designed porous structures varying in shape, porosity, pore size, pore geometry and pore interconnectivity can be prepared at high resolutions. It is envisaged that flexible and elastic scaffolds that resorb in the body will be highly applicable in the engineering of soft tissues such as cartilage or cardiovascular tissues.
Currently, no resins are available that can be processed by SLA to yield suitable porous structures. We describe the development of photo-crosslinkable resins based on biodegradable poly(trimethylene carbonate) (PTMC) and the processing of these resins by stereolithography to yield flexible porous and non-porous network structures.
报告人简历：
Dirk Grijpma is professor in Biomaterials Science and Technology at the University of Twente. He also holds a part-time position at the University Medical Center Groningen. His expertise is in the synthesis and properties of resorbable polymeric materials for use in medical devices, tissue engineering and in the delivery of relevant biologically compounds, and the interaction of these materials and devices with cells and tissues.
Current research includes the development of advanced microstructures by photo-polymerization of functionalized degradable oligomers in stereolithography and research programs on the tissue engineering of cardiac muscle, heart valve leaflets and blood vessels and the synthesis and processing of composite materials for fracture reconstruction in maxillofacial surgery. Pre-designed anisotropic architectures based on biologically active materials are being developed to engineer musculoskeletal and cardiovascular tissues in bioreactors under conditions that mimic the natural environment.
报告二：Adipose stem cells in bone and vascular tissue engineering
报告人: Dr. Haimi, Suvi Päivikki
Post doctoral researcher
Department of Biomaterials Science and Technology, University of Twente, The Netherlands
报告地点: 独墅湖校区907号楼1445报告厅
报告时间: 2012年5月31日上午10:30-11:00
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报告摘要：
Stem cells are desirable candidates for tissue engineering applications due to their ability to commit to multiple cell lineages. Adipose tissue, a mesodermally derived organ, has emerged as a promising source of multipotent adult stem cells. These adipose tissue derived stem cells (ASC)s are able to differentiate towards bone, vascular, and adipose tissue when cultured with suitable inducing factors. Furthermore, ASCs are abundant and can be efficiently harvested. At University of Twente and University of Tampere we have developed culture conditions to efficiently differentiate human ASCs towards osteogenic and vascular lineages. Recently, our research group at University of Tampere described the first case report of a microvascular custom-made ectopic bone flap employing autologous ASCs seeded on beta-tricalcium phosphate. This research successfully pioneered the production of large vascularized bone grafts for advanced treatments in general clinical settings.
高分子科学与工程系
博彩平台
2012-5-30
