报告题目：Development of Fluorescent Probes for Optical Imaging and Photo-Inactivation of Drug Resistant Bacteria
报告人： Dr. Bengang XING (Assoc. Prof.)
Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences, Nanyang Technological University
报告时间：2012年5月25日（星期五）下午 2:00 --- 3:30
报告地点：独墅湖校区907号楼1549
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报告简介：
Biologically specificity is mediated by the precise and selective regulation of protein ad enzyme functions in response to intrinsic development programs and extrinsic signals. In order to fully understand the protein or enzyme functions and further elucidate their mechanisms in biology, it is essential to apply a simple and reliable assay with high sensitivity and fidelity that can efficiently report the biological process of interest at the single cell or molecular level. In general, fluorescent imaging technique is among the most powerful methods for in vitro and in vivo detection of protein or enzyme functions because of their high sensitivity, relative safety, and easily handling. By studying the chemical reactions of enzyme or proteins with the fluorescence conjugated small molecule substrates, and meanwhile in vitro and in vivo evaluating their stability, cellular permeability and internalization properties, the specific enzymes or proteins activities and related biological pathways can be non-invasively monitored in a highly effective manner. In our group, a series of simple and specific fluorescent/bioluminescent probes have been designed and prepared to real-time visualize the special enzyme functions in vitro and in vivo. Moreover, the new approaches based on photodynamic antimicrobial chemotherapy (PACT) and fluorescent imaging technique towards the antibiotics resistant bacterial strains were also developed to understand the mechanisms of antibiotic activity and to investigate the drug resistance properties generated in bacterial pathogen strains.
Dr. Bengang XING简介：
Education
| 1994 2000 | BSc. (Chemistry Education), Chemistry Department, Xinjiang Normal University, China Ph. D. (Bioinorganic Chemistry), Chemistry Department, Nanjing University, China. Supervisor: Prof. Wenxia TANG |
Research Experience
| 2001-2003 | Research Associate, Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong. Supervisor: Prof. Bing XU |
| 2003-2004 | Postdoctoral Research Fellow, Crump Institute for Molecular Imaging, University of California, Los Angeles, USA. Supervisor: Prof. Jianghong RAO |
| 2004-2006 | Postdoctoral Researcher, Molecular Imaging Programs at Stanford University (MIPS), USA. Supervisor: Prof. Jianghong RAO |
| 2006-2011 2011- | Assistant Professor, Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore Associate Professor, Division of Chemistry and Biological Chemistry, Nanyang Technological University, Singapore |
Research Interests:
Fluorescent imaging, Bioorganic Chemistry, Bio-nanotechnology and Biomaterial sciences.
For more information about Dr. XING's research, please visit: //www3.ntu.edu.sg/home/bengang/.
应用化学研究所
博彩平台
2012-5-23
