报告题目：Evolution of Anion Relay Chemistry (ARC): Construction of Architecturally Complex Natural and Unnatural Products.
报告人： Amos B. Smith, III 教授
University of Pennsylvania
宾夕法尼亚大学
Philadelphia, PA, USA
报告时间：2012年5月23日（星期三）下午 2:00 --- 3:30
报告地点：独墅湖校区907号楼1101学术报告厅
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Amos B. Smith, III 教授个人简历：
Professor Amos B. Smith, III was awarded Bucknell University's first combined four-year B.S.-M.S. degree in Chemistry in 1966. After a year in medical school (University of Pennsylvania), he earned his Ph.D. degree (1972) and completed a year as a Research Associate at Rockefeller University. In 1973, he joined the Department of Chemistry at the University of Pennsylvania; currently, he is the Rhodes-Thompson Professor of Chemistry, a Member of the Monell Chemical Senses Center, the Associate Director of the Penn Center for Molecular Discovery (PCMD). From 1988 to 1996 he served as the Chairman of the Department of Chemistry. In 1998 he became the first Editor-in-Chief of Organic Letters. To date, Smith has co-authored over 600 publications and has delivered over 600 invited lectures.
报告摘要：
Anion Relay Chemistry (ARC), an effective multi-component union protocol recently developed and employed in our laboratory holds great potential for chemists requiring rapid increase of molecular complexity in a single operation with precise control of stereogenicity en route to both natural and “natural product-like” targets for biomedical research. Employing this technique, a large number of diverse structures can be rapidly assembled from a small number of initiating nucleophiles, bifunctional linchpins, and electrophiles in a controlled, multi-component coupling reaction. Recent efforts to expand the scope of this tactic to include the construction of natural products, as well as libraries of "natural product-like” compounds, highlight the robust nature of this protocol. The evolution of this tactic, involving both Type I and Type II ARC tactics will be presented with illustrations arising from alkaloid and polyketide/macrolide total synthetic ventures currently ongoing in our laboratory.
有机化学研究所
博彩平台
2012-5-18
