New understanding from intestinal absorption model: How physiological features influence mass transfer and absorption
Qin, Yifan1,2, Chen, Xiao Dong1, Yu, Aibing2,3, Xiao, Jie1(肖杰)
1School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu Province 215123,China
2Department of Chemical Engineering and Biological Engineering, Monash University,Clayton, Victoria 3800, Australia
3Southeast University-Monash University Joint Research Institute, Suzhou Industrial Park, Suzhou, Jiangsu Province 215123, China
Abstract：Mathematical modeling of mass transfer and absorption in the small intestine has been a challenging task. Systematic review and analysis of existing efforts indicate the need to pursue a reliable predictive model that is physically sound and computationally efficient. With the consideration of 3D intestinal inner wall structure, this work rigorously derives an absorption model that can be used as a source term in a 1D distributed model, conventionally called the diffusion-convection-reaction model. Moreover, computational fluid dynamics simulations are carried out to generate in silico experimental data for quantification of the mass-transfer coefficient in the absorption model. This model facilitates a better understanding of the intricate influence of intestinal morphology and motility on mass transfer and absorption in the intestine. Rat duodenum featuring a villous structure and pendular movement is selected as an example to demonstrate the capability of this approach.
链接：//aiche.onlinelibrary.wiley.com/doi/10.1002/aic.18099
