李杰

  姓名：李杰
  职称：教授

联系方式：jjackli@maxbocai.com

个人主页：//www.x-mol.com/groups/JieLi

2020.01‒至今苏州大学，博彩平台，教授

2017.10‒2019.11慕尼黑大学，化学院，Research Associate （合作导师：Prof. Paul Knochel）

2015.10‒2017.09江南大学，药学院，特聘研究员

2011.10‒2015.07哥廷根大学，有机化学（导师：Prof. Lutz Ackermann；博士论文获“summa cum laude”）

2008.09‒2011.10沈阳药科大学 & 中国医学科学院药物研究所，药物化学（导师：华会明教授 & 肖志艳研究员）

2004.09‒2008.06天津商业大学，制药工程

研究领域及经历：围绕新试剂、新反应的发展，积极开展基于试剂导向的合成有机化学研究。迄今，在包括Nat. Commun.（1篇）、J. Am. Chem. Soc.（3篇）、Angew. Chem., Int. Ed.（6篇）等期刊发表研究论文三十余篇。获得2021年度“Thieme Chemistry Journals Awardees”、入选2016年度江苏省“双创博士”、2015年博士论文荣获“summa cum laude”–优博，应邀在国际、国内科研院校做学术报告十余次。

代表性研究论文：

1. J. Wang, Z. Duan, X. Liu, S. Dong, K. Chen, J. Li*, Salt-Stabilized Silylzinc Pivalates for Nickel-Catalyzed Carbosilylation of Alkenes, Angew. Chem., Int. Ed., 2022, 61, e202202379.

2. Y. Hu, X. Liu, Z. Ren, B. Hu, J. Li*, Csp³‒H Monofluoroalkenylation via Stereoselective C‒F Bond Cleavage, Chem. Commun., 2022, 58, 2734-2737.

3. Y. Hu, B. Hu, X. Liu, Z. Ren, J. Li*, Recent Developments in Catalytic Cross-Couplings with Unsaturated Carboxylates, Org. Biomol. Chem., 2021, 19, 7754-7767.

4. X. Cheng, X. Liu, S. Wang, Y. Hu, B. Hu, A. Lei*, J. Li*, Organozinc Pivalates for Cobalt-Catalyzed Difluoroalkylarylation of Alkenes, Nat. Commun., 2021, 12, 4366‒4375.

5. B. Hu, X. Cheng, Y. Hu, X. Liu, K. Karaghiosoff, J. Li*, Rhenium-Catalyzed Aryl‐Acylcyclization between Enol Lactones and Organomagnesium Halides: Facile Synthesis of Indenones, Angew. Chem., Int. Ed., 2021, 60, 15497‒15502.

6. X. Cheng, X. Liu, S. Wang, Y. Hu, B. Hu, A. Lei*, J. Li*, Organozinc Pivalates for Cobalt-Catalyzed Difluoroalkylarylation of Alkenes and Mechanistic Insights, nature portfolio, 2021, DOI:10.21203/rs.3.rs-156355/v1.

7. Z. Zhang, H. Chen, N. Keller, Q. Xiong, L. Liu, Y. Lan*, T. Bein*, J. Li*, Dehydrogenative 6π Heterocyclization under Visible Light Irradiation and Mechanistic Insights. Org. Chem. Front., 2021, 8, 3788‒3795.

8. L. Liu, Mingran Si, Shengnan Han, Y. Zhang, J. Li*, Copper-Catalyzed Regioselective Sulfonylcyanation of Vinylarenes. Org. Chem. Front., 2020, 7, 2029‒2034.

9. L. Liu, Z. Zhang, Y. Wang, Y. Zhang, J. Li*, Electrophilic Amination with Anthranils through Cobalt(III)-Catalyzed C(sp³)‒H Activation. Synthesis 2020, 52, 3881‒3890.

10. J. Li*, Q. Ren, X. Cheng, K. Karaghiosoff, P. Knochel*, Chromium(II)-Catalyzed Diastereoselective and Chemoselective Csp²‒Csp³ Cross-Couplings Using Organomagnesium Reagents. J. Am. Chem. Soc., 2019, 141, 18127‒18135.

11. S. Han, S. Liu, L. Liu, L. Ackermann, J. Li*, Cobalt-Catalyzed Diastereoselective Difluoroalkyaltion/Giese Addition Domino Reactions. Org. Lett., 2019, 21, 5387‒5391.

12. J. Li*, P. Knochel*, Chromium-Catalyzed Cross-Couplings and Related Reactions. Synthesis 2019, 51, 2100‒2106.

13. J. Li*, E. Tan, N. Keller, Y.-H. Chen, P. M. Zehetmaier, A. C. Jakowetz, T. Bein*, P. Knochel*, Cobalt-Catalyzed Electrophilic Amination with Anthranils: An Expedient Route to Condensed Quinolines. J. Am. Chem. Soc., 2019, 141, 98‒103.

14. M. Tang, Y. Li, S. Han, L. Liu, L. Ackermann, J. Li*, Rhodium(III)-Catalyzed C‒H Alkylation/Nucleophilic Addition Domino Reaction. Eur. J. Org. Chem., 2019, 660‒664.

15. Y. Da, S. Han, X. Du, S. Liu, L. Liu, J. Li*, Copper(I)-Catalyzed Oxydifluoroalkylation of Alkenes: A Route to Functionalization Lactones. Org. Lett., 2018, 20. 5149‒5152.

16. J. Li, P. Knochel*, Cobalt-Catalyzed Cross-Couplings between Alkenyl Acetates and Aryl or Alkenyl Zinc Pivalates. Angew. Chem., Int. Ed., 2018, 57, 11436‒11440.

17. Liang-Hua Zou*, Cong Zhao, Ping-Gui Li, Ying Wang, J. Li*, Transition-Metal-Free C−S Bond Formation: Synthesis of Polysubstituted Diaryl Sulfides and αThioarylcarbonyl Compounds. J. Org. Chem., 2017, 82, 12892–12898.

18. X. Zhang*, H. Zheng, J. Li*, F. Xu, J. Zhao, H. Yan*, Selective Catalytic B–H Arylation of o-Carboranyl Aldehydes by a Transient Directing Strategy. J. Am. Chem. Soc., 2017, 139, 14511‒14517.

19. Z. Zhang, S. Han, M. Tang, L. Ackermann*, J. Li*, C–H Alkylations of (Hetero)Arenes by Maleimides and Maleate Ester through Versatile Cobalt(III) Catalysis. Org. Lett., 2017, 19, 3315–3318.

20. S. Han, W. Ma, Z. Zhang, L. Liu, M. Tang, J. Li*, Mild C(sp³)‒H Alkylation of 8-Methylquinolines with α,β-Unsaturated Carbonyl Compounds by Rhodium(III) Catalysis. Asain J. Org. Chem., 2017, 6, 1014‒1018.

21. J. Li*, Z. Zhang, W. Ma, M. Tang, D. Wang, L.-H. Zou, Mild Cobalt(III)-Catalyzed C‒H Hydroarylation of Conjugated C＝C/C＝O Bonds. Adv. Synth. Catal., 2017, 359, 1717–1724.

22. M. Moselage^†, J. Li^†(Co-first author), F. Kramm, L. Ackermann*, Ruthenium(II)-Catalyzed Decarbamoylative C–C Arylations and Alkylations. Angew. Chem., Int. Ed., 2017, 55, 5341–5344.

23. Z. Zhang, M. Tang, S. Han, L. Ackermann, J. Li*, Carboxylate Enhanced Rhodium(III)-Catalyzed Aryl C–H Alkylation with Conjugated Alkenes under Mild Conditions. J. Org. Chem., 2017, 82, 664–672.

24. W. Ma*, P. Gandeepan*, J. Li, L. Ackermann*, Recent Advances in Positional-Selective Alkenylations: Removable Guidance for Twofold C‒H Activation. Org. Chem. Front., 2017, 4, 1435‒1467.

25. Z. Zhang, M. Tang, L. Zang, L.-H. Zou, J. Li*, Thermolysis of 2-Diazo-3-aryl ketoesters: New Route to α-Aryl Malonates and Aromatic Esters. Tetrahedron Lett., 2016, 57, 5681–5684.

26. J. Li*, Z. Zhang, M. Tang, X. Zhang, J. Jin, Selective Synthesis of Isoquinolines by Rhodium(III)-Catalyzed C–H/N–H Functionalization with α-Substituted Ketones. Org. Lett., 2016, 18, 3898–3901.

27. J. Li*, M. Tang, L. Zang, X. Zhang, Z. Zhang, L. Ackermann*, Amidines for Versatile Cobalt(III)-Catalyzed Synthesis of Isoquinolines through C–H Functionalization with Diazo Compounds. Org. Lett., 2016, 18, 2742–2745.

28. M. Moselage^†, J. Li^†(Co-first author), L. Ackermann*, Cobalt-Catalyzed C–H Activation. ACS Catal., 2016, 6, 498–525.

29. J. Li, L. Ackermann*, Cobalt-Catalyzed C–H Cyanation of Arenes and Heteroarenes. Angew. Chem., Int. Ed., 2015, 54, 3635–3638.

30. J. Li, L. Ackermann*, Cobalt(III)-Catalyzed Aryl and Alkenyl C–H Aminocarbonylation with Isocyanates and Acyl Azides. Angew. Chem., Int. Ed., 2015, 54, 8551–8554.

31. J. Li, L. Ackermann*, Cobalt-Catalyzed C–H Arylations with Weakly-Coordinating Amindes and Tetrazoles: Expedient Route to Angiotensin-II-Receptor Blockers. Chem. Eur. J., 2015, 21, 5718–5722.

32. J. Li, L. Ackermann*, Carboxylate-Assisted Ruthenium(II)-Catalyzed C–H Activations of Monodentate Amides with Conjugated Alkenes. Org. Chem. Front., 2015, 2, 1035–1039.

33. J. Li, M. John, L. Ackermann*, Amidines for Versatile Ruthenium(II)-Catalyzed Oxidative C–H Activations with Internal Alkynes and Acrylates. Chem. Eur. J., 2014, 20, 5403–5408.

34. J. Li, L. Ackermann*, Ruthenium-Catalyzed Oxidative Alkyne Annulation by C–H Activation on Ketimines. Tetrahedron 2014, 70, 3342–3348.

35. J. Li, H.-M. Hua, Y-B. Tang, S. Zhang, E. Ohkoshi, K.-H Lee, Z. Xiao*, Synthesis and Evaluation of Novel Podophyllotoxin Analogs. Bioorg. Med. Chem. Lett., 2012, 22, 4293–4295.