博彩平台

Tel: 86-512-65884933 (o)

Fax: 86-512-65884933

Email: cdeng@maxbocai.com

Professor (Polymer Chemistry)

Ph.D. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (2006)

Postdoc, University of Ottawa (2006-2010)

Research Interests: functional polypeptides, polymeric nanomedicines, microgels, and nanogels.

学历及学术经历:2006年中科院长春应用化学所获博士学位，2006-2010年加拿大渥太华大学眼睛所、心脏所和细胞分子生物医学系博士后，2010年6月起受聘为苏州大学副教授，2014年晋升为教授。在国际主流期刊如Prog. Polym. Sci., Small, Biomaterials, Nano Today, Chem. Mater., J. Control. Release, Macromolecules, Acta Biomater., Biomacromolecules 等上发表论文100多篇，被引用7600多次，H-因子45。多篇论文被MaterialsViewChina,中国聚合物网和高分子科技等作为研究亮点进行专题报道。申请中国发明专利12项和国际发明专利2项，授权中国发明专利7项。担任了五届“新型高分子材料与控制释放国际会议”（SIPCD 2010, 2012, 2014, 2016, 2018）”的秘书长，多次在国际会议上作报告。现主持两项国家自然科学基金。曾获加拿大心脏及中风基金委研究奖学金，渥太华心脏研究所分子功能和图像研究奖学金，苏州市高等院校、科研院所紧缺高层次人才资助，2018年度药理学和毒理学领域全球高被引科学家（科睿唯安，Clarivate Analytics）。

研究领域：功能性聚多肽的设计合成，聚多肽纳米药物载体，微米凝胶，纳米凝胶等。

Representative Publications

1.X.L. Gu, Z.H. Zhu, Q.Y. Fan, Y.H. Wei, G.L. Wang, F.H. Meng, Z.Y. Zhong*, and C. Deng*, Nanoagents based on poly(ethylene glycol)-b-poly(L-thyroxine) block copolypeptide for enhanced dual-modality imaging and targeted tumor radiotherapy, Small2019, 1902577.

2.X.L. Gu, Y.H. Wei, Q.Y. Fan, H.L. Sun, R. Cheng, Z.Y. Zhong*, and C. Deng*, cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo, J. Control. Release2019, 301, 110-118.

3.K. Huang, Y.H. He, Z.H. Zhu, J.K. Guo, G.L. Guang, C. Deng*, and Z.Y. Zhong*, Small, traceable, endosome-disrupting, and bioresponsive click nanogels fabricated via microfluidics for CD-targeted cytoplasmic delivery of therapeutic proteins, ACS Appl. Mater. Interfaces2019, 11, 22171-22180.

4.M. Qiu, J. Ouyang, Y.H. Wei, J. Zhang, Q. Lan, C. Deng*, and Z.Y. Zhong*, Selective cell penetrating peptide-functionalized envelope-type chimeric lipopepsomes boost systemic RNAi therapy for lung tumors, Adv. Healthcare. Mater.2019, 8, 1900500.

5.H.M. Fang, X.F. Zhao, X.L. Gu, H.L. Sun, R. Cheng, Z.Y. Zhong*, and C. Deng*, CD44-targeted multifunctional nanomedicines based on a single-component hyaluronic acid conjugate with all-natural precursors: construction and treatment of metastatic breast tumors in vivo, Biomacromolecules2019, DOI: 10.1021/acs.biomac.9b01012.

6.H.Z. Qin, Y. Jiang, J. Zhang, C. Deng*, and Z.Y. Zhong*, Oncoprotein inhibitor rigosertib loaded in apoe-targeted smart polymersomes reveals high safety and potency against human glioblastoma in mice, Mol. Pharmaceutics2019, 16, 3711-3719.

7.J. Chen, H. He, C. Deng*, L.C. Yin, and Z.Y. Zhong*, Saporin-loaded CD44 and EGFR dual-targeted nanogels for potent inhibition of metastatic breast cancer in vivo, Int.J. Pharm. 2019, 560, 57-64.

8.D. Kuraitis, K. Hosoyama, N. J. R. Blackburn, C. Deng, Z. Zhong*, E. J. Suuronen*, Functionalization of soft materials for cardiac repair and regeneration. Crit. Rev. Biotechnol.2019, 39, 451-468.

9.N. Rades, K. Achazi, M. Qiu, C. Deng, R. Haag, Z.Y. Zhong*, and K. Licha*, Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs, J. Control. Release2019, 300, 13-21.

10.M. Qiu, H.L. Sun, F.H. Meng, R. Cheng, J. Zhang, C. Deng*, and Z.Y. Zhong*, Lipopepsomes: A novel and robust family of nano-vesicles capable of highly efficient encapsulation and tumor-targeted delivery of doxorubicin hydrochloride in vivo, J. Control. Release2018, 272, 107-113.

11.M. Qiu, X.X. Wang, H.L. Sun, J. Zhang, C. Deng*, and Z.Y. Zhong*, Cyclic RGD-peptide-functionalized polylipopeptide micelles for enhanced loading and targeted delivery of monomethyl auristatin E, Mol. Pharmaceutics2018, 15, 4854-4861.

12.J. Chen, K. Huang, Q.J. Chen, C. Deng*, J. Zhang, and Z.Y. Zhong*, Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumor, ACS Appl. Mater. Interfaces2018, 10, 3929-3937.

13.M. Qiu, Z.Q. Zhang, Y.H. Wei, H.L. Sun, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Small-sized and robust chimaeric lipopepsomes: A simple and functional platform with high protein loading for targeted intracellular delivery of protein toxin in vivo, Chem. Mater. 2018, 30, 6831-6838.

14.S. Xue, X.L. Gu, J. Zhang, H.L. Sun, C. Deng*, and Z.Y. Zhong*, Construction of small-sized, robust, and reduction-responsive polypeptide micelles for high loading and targeted delivery of chemotherapeutics, Biomacromolecules 2018, 19, 3586-3593.

15.X.L. Gu, M. Qiu, H.L. Sun, J. Zhang, L. Cheng, C. Deng*, and Z.Y. Zhong*,Polytyrosine nanoparticles enable ultra-high loading of doxorubicin and rapidly enzyme-responsive drug release, Biomater.Sci.2018, 6, 1526-1534.

16.T. Chen, M. Qiu, J. Zhang, H.L. Sun, C. Deng*, and Z.Y. Zhong*, Integrated Multifunctional Micelles Co-Self-Assembled from Polypeptides Conjugated with Natural Ferulic Acid and Lipoic Acid for Efficient and Bioresponsive Doxorubicin Delivery, ChemPhysChem2018, 19, 2070-2077.

17.M. Qiu, J. Ouyang, H.L. Sun, F.H. Meng, R. Cheng, J. Zhang, L. Cheng, Q. Lan, C. Deng*, and Z.Y. Zhong*, Biodegradable Micelles Based on Poly(ethylene glycol)-b-Polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery, ACS Appl. Mater. Interfaces2017, 9, 27587-27595.

18.J. Chen, J. Ouyang, Q.J. Chen, C. Deng*, F.H. Meng, J. Zhang, R. Cheng, Q. Lan, and Z.Y. Zhong*, EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo, ACS Appl. Mater. Interfaces2017, 9, 24140-24147.

19.J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, Robust, Responsive and Targeted PLGA Anticancer Nanomedicines by Combining Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating, ACS Appl. Mater. Interfaces2017, 9, 3985-3994.

20.J.T. Wu, C. Deng*, F.H. Meng, J. Zhang, H.L. Sun, and Z.Y. Zhong*, Hyaluronic Acid Coated PLGA Nanoparticulate Docetaxel Effectively Targets and Suppresses Orthotopic Human Lung Cancer, J. Control. Release2017, 259, 76-82.

21.J. Chen, Y. Zou, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment In Vivo, Chem. Mater.2016, 28, 8792-8799.

22.S. Li, J. Zhang, C. Deng*, F.H. Meng, L. Yu, and Z.Y. Zhong*, Redox-Sensitive and Intrinsically Fluorescent Photoclick Hyaluronic Acid Nanogels for Traceable and Targeted Delivery of Cytochrome C to Breast Tumor In Mice, ACS Appl. Mater. Interfaces2016, 8, 21155-21162.

23.B.F. Sun, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Robust, Active Tumor-Targeting and Fast Bioresponsive Anticancer Nanotherapeutics Based on Natural Endogenous Materials, Acta Biomaterialia2016, 45, 223-233.

24.J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, and Z.Y. Zhong*, Vitamin E-Oligo(methyl diglycol L-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles, Biomacromolecules2016, 17, 2367-2374.

25.P.P. Chen, M. Qiu, C. Deng*, F.H. Meng, J. Zhang, R. Cheng, and Z.Y. Zhong*, pH-Responsive Chimaeric Pepsomes Based on Asymmetric Poly(ethylene glycol)-b-Poly(L-leucine)- b-Poly(L-glutamic acid) Triblock copolymer for Efficient Loading and Active Intracellular Delivery of Doxorubicin Hydrochloride, Biomacromolecules2015, 16, 1322-1330.

26.G.H. Xu, X.L. Wang, C. Deng*, X.M. Teng, E.J. Suuronen, Z.Y. Shen*, and Z.Y. Zhong*, Injectable Biodegradable Hybrid Hydrogels based on Thiolated Collagen and Oligo(acryloyl carbonate)-Poly(ethylene glycol)-oligo(acryloyl carbonate) Copolymer for Functional Cardiac Regeneration, Acta Biomater. 2015, 15, 55-64.

27.C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci.2014, 39, 330-364.

28.Y.J. Jiang, J. Chen, C. Deng*, E.J. Suuronen, and Z.Y. Zhong*, Click Hydrogels, Microgels and Nanogels: Emerging Platforms for Drug Delivery and Tissue Engineering, Biomaterials2014, 35, 4969-4985.

29.Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy, Biomacromolecules2014, 15, 1955-1969.

30.W. Chen, Y. Zou, F.H. Meng, R. Cheng, C. Deng*, J. Feijen, and Z.Y. Zhong*, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Delivery of Anticancer Drugs, Biomacromolecules2014, 15, 900-907.

31.W.W. Guo, M. Zheng, Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Poly(ethylene oxide)-graft-Methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity, Chin. J. Chem.2014, 32, 57-65.

32.L.L. Wu, Y. Zou, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions, Biomaterials2013, 34, 5262-5272.

33.J.R. Zhou, P.P. Chen, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted L-Cysteine N-Carboxyanhydride, Macromolecules2013, 46, 6723–6730.

34.Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules2013, 14, 3723-3730.

35.Y.P. Fan, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry, Biomacromolecules2013, 14, 2814-2821.

36.C. Deng, Y.J. Jiang, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Biodegradable Polymeric Micelles for Targeted and Controlled Anticancer Drug Delivery: Promises, Progress and Prospects, Nano Today2012, 7, 467-480.

37.Y.X. Yu, C. Deng, F.H. Meng, Q. Shi, J. Feijen, and Z.Y. Zhong*, Novel Injectable Biodegradable Glycol Chitosan-Based Hydrogels Crosslinked by Michael-Type Addition Reaction with Oligo(acryloyl carbonate)-b-Poly(ethylene glycol)-b- ligo(acryloyl carbonate) Copolymers, J. Biomed. Mater. Res. Part A2011, 99A, 316-326.

38.C. Deng, P. Zhang, B. Vulesevic, D. Kuraitis, F. Li, A.F. Yang, M. Griffith, M. Ruel, and E.J. Suuronen*, A Collagen-Chitosan Hydrogel for Endothelial Differentiation and Angiogenesis, Tissue Eng. Part A2010, 16, 3099-3109.

39.C. Deng, F.F. Li*, J.M. Hackett, S.H. Chaudhry, F.N. Toll, B. Toye, W. Hodge, and M. Griffith*, Collagen and Glycopolymer Based Hydrogel for Potential Corneal Application, Acta Biomater.2010, 6, 187-94.