NBS-induced intramolecular annulation reactions for the divergent synthesis of fused- and spirocyclic indolines
Xian Luo 1 , Meng-Meng Xu 1 , Xiao-Ping Xu 1, 2（徐小平） , Shun-Jun Ji 1, 3（纪顺俊）
1 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
2 Innovation Center for Chemical Science, Soochow University, China.
3 Suzhou Baolidi Functional Materials Research Institute, Suzhou 215144, People's Republic of China.
Chem. Commun., 2023, 59, 6576--6579
An NBS-induced intramolecular annulation of 3-(1H-indol-3-yl)-N-alkoxypropanamide is described. The reactions proceed well and quickly under mild conditions with the help of a base. It was found
that C2-substituents on the indole ring in 3-(1H-indol-3-yl)-N-alkoxypropanamide have a great influence upon the reaction. By using C2-methyl- and C2-phenyl-3-(1H-indol-3-yl)-N-alkoxypropanamide as templates, practical protocols for the divergent synthesis of fused- and spirocyclic indoline compounds were studied and established.
链接：//pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC01920A
