COAP/Pd-Catalyzed Linear Asymmetric Allylic Alkylation for Optically Active 3,3-Disubstituted Oxindole Derivatives with a FourCarbon Amino Side Chain
Wen-Kai Liu, Bai-Lin Wang, Sheng-Suo Zhou, Jun-Hao Shen, Zheng Wang*（王正）, and Xing-Wang Wang*（王兴旺）
1 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
2 State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China
Org. Lett.2023, 25, 104--108
An asymmetric linear selective allylic alkylation of vinylaziridines with 3-aryl oxindoles has been
developed by using a chiral oxamide-phosphine (COAP-Bn-OMe-p)/palladium complex in methanol, which furnished a wide variety of 3,3-disubstituted oxindole derivatives in good yields with excellent regio- and enantioselectivities.
链接：//pubs.acs.org/doi/10.1021/acs.orglett.2c03902
