Light-Induced 1,3-Thiosulfonylation of β,γ-Unsaturated Ketones with ThiosulfonatesClick to copy article link
Jiuwen Xu, Bo-Xi Liu, Xin-Yu Liu, Weidong Rao, Shun-Yi Wang（汪顺义）*
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China
Org. Lett. 2024, 26, 6798−6802
ABSTRACT: Sulfur-containing compounds exhibit potent significance in drugmolecules. Thiosulfonates as 1,3-thiosulfonylation reactants to olefins have yet to beinvestigated. Herein, we report photoinduced 1,3-difunctionalization of β,γ-unsaturated ketones with thiosulfonates, which undergo a radical 1,2-acyl shift.The protocol features mild conditions, high regioselectivity, and 100% atomeconomy.
链接：//pubs.acs.org/doi/10.1021/acs.orglett.4c01925
